Meaning you want like another ctrl or alt command to go with the numbers or something? Im not quite following but maybe you would get a better idea from my layout.
The way i have it layed out is rotation from 1-7 on the keyboard, then alt + 1 - all the way to 12 on the nagas side buttons, it makes it much easier to sort out utility spells and for them to be instantly accessible. With these spells i have things like chains of ice, deathgrip, ghoul stun etc. then unbound a and d and replaced them with other spells. Then this allows me to be completly mobile whilst maintaining the easyness of casting spells without having to use effort to reach for things like ctrl or alt

My naga's side buttons are regarded as straight 1-9 then 0-= So generally im asking how to make my nagas buttons have an alt consideration everytime i push. I apologise for poor wording, ill try and break it down to tard talk.
pliz make my nagas 1 button alt + 1 without pushing alt
Only recently started using it as recieved as a gift while on my break from wow. But yeah i unbound my q and e and bound strafe to ad to free up qe for deterence and feign death, so i am intending for a similar keyboard layout to yours.